Structure of PDB 8wqb Chain E

Receptor sequence
>8wqbE (length=86) Species: 9606 (Homo sapiens) [Search protein sequence]
RFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCIECQANQASATSEECTV
AWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKY
3D structure
PDB8wqb Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2)
ChainE
Resolution3.37 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
2.3.2.32: cullin-RING-type E3 NEDD8 transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E C53 C56 H82 C33 C36 H62
BS02 ZN E C42 H80 C83 C22 H60 C63
BS03 ZN E C75 H77 C94 D97 C55 H57 C74 D77
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:8wqb, PDBe:8wqb, PDBj:8wqb
PDBsum8wqb
PubMed38670995
UniProtP62877|RBX1_HUMAN E3 ubiquitin-protein ligase RBX1 (Gene Name=RBX1)

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