Structure of PDB 8uw1 Chain E

Receptor sequence
>8uw1E (length=91) Species: 8355 (Xenopus laevis) [Search protein sequence]
TVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQE
ASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
3D structure
PDB8uw1 Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch.
ChainE
Resolution2.88 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E T45 R63 R72 R83 F84 V117 T118 T1 R19 R28 R39 F40 V73 T74
BS02 dna E V46 R63 L65 R69 V2 R19 L21 R25
External links
PDB RCSB:8uw1, PDBe:8uw1, PDBj:8uw1
PDBsum8uw1
PubMed39196936
UniProtP84233|H32_XENLA Histone H3.2

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