Structure of PDB 8uvq Chain E

Receptor sequence

>8uvqE (length=746) Species: 9606 (Homo sapiens) [Search protein sequence]

RPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIV
LSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDD
TVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVHGGMRAVEFKVVETDPS
PYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVE
LPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLING
PEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVE
RRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGI
PDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQ
AIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEV
PQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPG
CGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAP
CVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIG
ATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVD
LEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIRRERERQTNPSEDD
PVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFR

3D structure

PDB

8uvq Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors.

Chain

Resolution

3.42 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	ADP	E	G207 G248 T249 G250 T252 L253 H384 A409	G186 G227 T228 G229 T231 L232 H363 A388
BS02	ADP	E	I479 G480 G521 C522 G523 K524 T525 L526 N624 I656 G684 T688	I458 G459 G500 C501 G502 K503 T504 L505 N603 I635 G663 T667
BS03	XO8	E	L492 V493 P496 V497 F503 G507 M508 P510 K512 C535 A537 P571 K615 N616 F618	L471 V472 P475 V476 F482 G486 M487 P489 K491 C514 A516 P550 K594 N595 F597

External links

PDB	RCSB:8uvq, PDBe:8uvq, PDBj:8uvq
PDBsum	8uvq
PubMed	39122922
UniProt	P55072\|TERA_HUMAN Transitional endoplasmic reticulum ATPase (Gene Name=VCP)

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