Structure of PDB 8uk9 Chain E

Receptor sequence
>8uk9E (length=318) Species: 10665 (Tequatrovirus T4) [Search protein sequence]
ITVNEKEHILEQKYRPSTIDECILPAFDKETFKSITSKGKIPHIILHSPS
PGTGKTTVAKALCHDVNADMMFVNGSDCKIDFVRGPLTNFASAASFDGRQ
KVIVIDEFCRSGLAESQRHLRSFMEAYSSNCSIIITANNIDGIIKPLQSR
CRVITFGQPTDEDKIEMMKQMIRRLTEICKHEGIAIADMKVVAALVKKNF
PDFRKTIGELDSYSSKGVLDAGILSLVTNDRGAIDDVLESLKNKDVKQLR
ALAPKYAADYSWFVGKLAEEIYSRVTPQSIIRMYEIVGENNQYHGIAANT
ELHLAYLFIQLACEMQWK
3D structure
PDB8uk9 Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM
ChainE
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E K80 I81 R85 K79 I80 R84
BS02 ADP E E12 R16 P17 C23 I24 L25 G53 T54 G55 K56 T57 T58 R205 E11 R15 P16 C22 I23 L24 G52 T53 G54 K55 T56 T57 R204
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication
Cellular Component
GO:0005663 DNA replication factor C complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uk9, PDBe:8uk9, PDBj:8uk9
PDBsum8uk9
PubMed38177685
UniProtP04526|LOADL_BPT4 Sliding-clamp-loader large subunit (Gene Name=44)

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