Structure of PDB 8uh7 Chain E

Receptor sequence
>8uh7E (length=314) Species: 10663 (Tequatrovirus) [Search protein sequence]
ITVNEKEHILEQKYRPSTIDECILPAFDKETFKSITSKGKIPHIILHSPS
PGTGKTTVAKALCHDVNADMMFVNGSDCKIDFVRGPLTNFASAASFDGRQ
KVIVIDEFDRSGLAESQRHLRSFMEAYSSNCSIIITANNIDGIIKPLQSR
CRVITFGQPTDEDKIEMMKQMIRRLTEICKHEGIAIADMKVVAALVKKNF
PDFRKTIGELDSYSSKGVLDAGILSLVGAIDDVLESLKNKDVKQLRALAP
KYAADYSWFVGKLAEEIYSRVTPQSIIRMYEIVGENNQYHGIAANTELHL
AYLFIQLACEMQWK
3D structure
PDB8uh7 Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM
ChainE
Resolution2.628 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E K80 I81 R85 K79 I80 R84
BS02 ADP E E12 P17 C23 I24 G53 T54 G55 K56 T57 T58 F204 R205 E11 P16 C22 I23 G52 T53 G54 K55 T56 T57 F203 R204
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication
Cellular Component
GO:0005663 DNA replication factor C complex

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Cellular Component
External links
PDB RCSB:8uh7, PDBe:8uh7, PDBj:8uh7
PDBsum8uh7
PubMed38177685
UniProtP04526|LOADL_BPT4 Sliding-clamp-loader large subunit (Gene Name=44)

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