Structure of PDB 8u8v Chain E

Receptor sequence

>8u8vE (length=990) Species: 9606 (Homo sapiens)

SGQQQRLLAFFKCCLLTDQLPLAHHLLVVHHGQRQKRKLLTLDMYNAVML
GWARQGAFKELVYVLFMVKDAGLTPDLLSYAAALQCMGRQDQDAGTIERC
LEQMSQEGLKLQALFTAVLLSEEDRATVLKAVHKVKPTFSLPPQLPPPVN
TSKLLRDVYAKDGRVSYPKLHLPLKTLQCLFEKQLHMELASRVCVVSVEK
PTLPSKEVKHARKTLKTLRDQWEKALCRALRETKNRLEREVYEGRFSLYP
FLCLLDEREVVRMLLQVLQALPAQGESFTTLARELSARTFSRHVVQRQRV
SGQVQALQNHYRKYLCLLASDAEVPEPCLPRQYWEALGAPEALREQPWPL
PVQMELGKLLAEMLVQATQMPCSLDKPHRSSRLVPVLYHVYSFRNVQQIG
ILKPHPAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHSGAFLLSPTK
LMRTVEGATQHQELLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQ
LFQAKGCPQLGVPAPPSEAPQPPEAHLPHSAAPARKAELRRELAHCQKVA
REMHSLRAEALYRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHLGSD
VARALLEFAQGRPLGPHGLDWLKIHLVNLTGLKKREPLRKRLAFAEEVMD
DILDSADQPLTGRKWWMGAEEPWQTLACCMEVANAVRASDPAAYVSHLPV
HQDGSCNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVAAQVEVFRRQ
DAQRGMRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRELSD
FPQEFVWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGSVVE
WVTPLGVPVIQPYRLDSRKPNTRKQKNGFPPNFIHSLDSSHMMLTALHCY
RKGLTFVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVKR
FCSEPQKILEASQLKETLQAVPKPGAFDLEQVKRSTYFFS

3D structure

• PDB: 8u8v Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
• Chain: E
• Resolution: 2.74 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	E	N614 H1150	N395 H910
BS02	dna	E	Q493 R613 Q766 S774 R803 P811 H812 T996 G1000 T1002 Y1004 G1005 Q1009 Y1082	Q274 R394 Q547 S555 R584 P592 H593 T777 G781 T783 Y785 G786 Q790 Y863
BS03	APC	E	S924 G927 R987 Q992 M995 Y999 H1125	S705 G708 R768 Q773 M776 Y780 H885
BS04	MG	E	D922 G923 D1151	D703 G704 D911

External links

• PDB: RCSB:8u8v, PDBe:8u8v, PDBj:8u8v
• PDBsum: 8u8v
• PubMed: 39164235
• UniProt: O00411|RPOM_HUMAN DNA-directed RNA polymerase, mitochondrial (Gene Name=POLRMT)