Structure of PDB 8u8u Chain E

Receptor sequence
>8u8uE (length=985) Species: 9606 (Homo sapiens) [Search protein sequence]
QLSGQQQRLLAFFKCCLLTDQLPLAHHLLVVHHGQRQKRKLLTLDMYNAV
MLGWARQGAFKELVYVLFMVKDAGLTPDLLSYAAALQCMGRQDQDAGTIE
RCLEQMSQEGLKLQALFTAVLLSEEDRATVLKAVHKVKPTFSLPPQLPPP
VNTSKLLRDVYAKDGRVSYPKLHLPLKTLQCLFEKQLHMELASRVCVVSV
EKPTLPSKEVKHARKTLKTLRDQWEKALCRALRETKNRLEREVYEGRFSL
YPFLCLLDEREVVRMLLQVLQALPAQGESFTTLARELSARTFSRHVVQRQ
RVSGQVQALQNHYRKYLCLLASDAEVPEPCLPRQYWEALGAPEALREQPW
PLPVQMELGKLLAEMLVQATQMPCSSRLVPVLYHVYSFRNVQQIGILKPH
PAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHSGAFLLSPTKLMRTV
EGATQHQELLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQLFQAK
GCPQLGVPAPPSEAPQPPEAHLPHSAAPARKAELRRELAHCQKVAREMHS
LRAEALYRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHLGSDVARAL
LEFAQGRPLGPHGLDWLKIHLVNLTGLKKREPLRKRLAFAEEVMDDILDS
ADQPLTGRKWWMGAEEPWQTLACCMEVANAVRASDPAAYVSHLPVHQDGS
CNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVAAQVEVFRRQDAQRG
MRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRELSDFPQEF
VWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGSVVEWVTPL
GVPVIQPYRLDSRKPNTRKQKNGFPPNFIHSLDSSHMMLTALHCYRKGLT
FVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVKRFCSEP
QKILEASQLKETLQAVPKPGAFDLEQVKRSTYFFS
3D structure
PDB8u8u Structural basis for substrate binding and selection by human mitochondrial RNA polymerase.
ChainE
Resolution2.9 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna E N614 G817 H1150 N390 G593 H905
BS02 dna E Q493 R613 R672 R759 L762 Q766 S774 E778 R803 P811 Y999 G1000 V1001 T1002 Y1004 G1005 Q1009 Y1082 Q276 R389 R448 R535 L538 Q542 S550 E554 R579 P587 Y775 G776 V777 T778 Y780 G781 Q785 Y858
BS03 APC E K991 M995 Y999 K767 M771 Y775
External links
PDB RCSB:8u8u, PDBe:8u8u, PDBj:8u8u
PDBsum8u8u
PubMed39164235
UniProtO00411|RPOM_HUMAN DNA-directed RNA polymerase, mitochondrial (Gene Name=POLRMT)

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