Structure of PDB 8ti2 Chain E

Receptor sequence
>8ti2E (length=1403) Species: 10036 (Mesocricetus auratus) [Search protein sequence]
MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIG
WGSQSSKVHIHHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTE
SRHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITK
TIKFVKFYDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKT
PREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAI
GKLPIAMRALTNYQRLCVAFDAPQGARAIWRALCHAFGRRLILSSTFRIL
ADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEFLGNAYVL
AVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLS
MGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGV
SALIGAAVIILLAPVQYFVATKLSQAQRSTLEHSNERLKQTNEMLRGMKL
LKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLIT
FVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVK
KLSEFLSNFCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCG
KSSLLLATLGEMQKVSGAVFWNSNLSRGPVAYASQKPWLLNATVEENITF
ESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISV
ARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHK
LQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHPWRACTKYLSSAG
ILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALVDQSVYAMVFTLLCSLG
IVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRF
SSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVC
YFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQ
KLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRE
LSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHALLKTEAES
YEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKI
GICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSII
LQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAII
TEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVM
TAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPETLLSQKDSVFA
SFV
3D structure
PDB8ti2 Structure of an open K ATP channel reveals tandem PIP 2 binding sites mediating the Kir6.2 and SUR1 regulatory interface.
ChainE
Resolution3.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PT5 E F38 F132 K134 L135 I137 F38 F132 K134 L135 I137
BS02 P5S E H61 I118 H125 N126 L364 H61 I118 H125 N126 L356
BS03 P5S E I76 R298 F305 L368 F372 I76 R290 F297 L360 F364
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
GO:0098662 inorganic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ti2, PDBe:8ti2, PDBj:8ti2
PDBsum8ti2
PubMed38509107
UniProtA0A1S4NYG1

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