Structure of PDB 8ti1 Chain E

Receptor sequence
>8ti1E (length=1141) Species: 10036 (Mesocricetus auratus) [Search protein sequence]
MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIG
WGSQSSKVHIHHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTE
SRHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITK
TIKFVKFYDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKT
PREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAI
GKLPIAMRALTNYQRLCVAFDAPQGARAIWRALCHAFGRRLILSSTFRIL
ADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEFLGNAYVL
AVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLS
MGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGV
SALIGAAVIILLAPVQYFVATKLSQAQRSTLEHSNERLKQTNEMLRGMKL
LKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLIT
FVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVK
KLSEFLSNFCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCG
KSSLLLATLGEMQKVSGAVFWNSNLSRGPVAYASQKPWLLNATVEENITF
ESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISV
ARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHK
LQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHPWRACTKYLSSAG
ILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALVDQSVYAMVFTLLCSLG
IVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRF
SSDCNTIDQHIPSTLECLSRSTLLCVSALTVISYVTPVFLVALLPLAVVC
YFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQ
KLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRE
LSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIH
3D structure
PDB8ti1 Structure of an open K ATP channel reveals tandem PIP 2 binding sites mediating the Kir6.2 and SUR1 regulatory interface.
ChainE
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PT5 E F38 F132 K134 L135 I137 F38 F132 K134 L135 I137
BS02 P5S E H61 I118 H125 N126 L364 H61 I118 H125 N126 L356
BS03 P5S E I76 R298 F305 L368 F372 I76 R290 F297 L360 F364
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
GO:0098662 inorganic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ti1, PDBe:8ti1, PDBj:8ti1
PDBsum8ti1
PubMed38509107
UniProtA0A1S4NYG1

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