Structure of PDB 8tas Chain E

Receptor sequence

>8tasE (length=570) Species: 9606 (Homo sapiens) [Search protein sequence]

KRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQ
PVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPL
QQNFMVHGDRECGFINDEIFVELVNALGQYSDKIFEAISSMFPDKGTAEE
LKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRC
FKYDCFLHFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTP
PENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSI
IAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHP
RQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLA
VRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGI
FIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVD
ATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDY
RYSQADALKYVGIEREMEIP

3D structure

PDB

8tas Activation of automethylated PRC2 by dimerization on chromatin

Chain

Resolution

4.1 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	E	K500 R502 C567 K568 A569 Q575	K319 R321 C386 K387 A388 Q394
BS02	SAH	E	A627 G628 W629 M667 C668 S669 F670 N693 H694 Y731 Y741 V742 I744	A446 G447 W448 M486 C487 S488 F489 N512 H513 Y550 Y560 V561 I563

External links

PDB	RCSB:8tas, PDBe:8tas, PDBj:8tas
PDBsum	8tas
PubMed
UniProt	Q15910\|EZH2_HUMAN Histone-lysine N-methyltransferase EZH2 (Gene Name=EZH2)

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