Structure of PDB 8t42 Chain E

Receptor sequence
>8t42E (length=430) Species: 9606 (Homo sapiens) [Search protein sequence]
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVY
YNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNN
WAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTL
LISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETY
CIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADL
RKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVK
TAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTG
EGMDEMEFTEAESNMNDLVSEYQQYQDATA
3D structure
PDB8t42 Structural basis for alpha-tubulin-specific and modification state-dependent glutamylation.
ChainE
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G2P E C12 Q15 G98 S138 T143 Y222 N226 C12 Q15 G98 S138 T143 Y222 N226
BS02 MG E D67 E69 D67 E69
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019904 protein domain specific binding
GO:0031625 ubiquitin protein ligase binding
GO:0032794 GTPase activating protein binding
GO:0042288 MHC class I protein binding
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
GO:0030705 cytoskeleton-dependent intracellular transport
GO:0042267 natural killer cell mediated cytotoxicity
GO:0050807 regulation of synapse organization
GO:0051225 spindle assembly
GO:0051301 cell division
GO:0071895 odontoblast differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005641 nuclear envelope lumen
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
GO:0032991 protein-containing complex
GO:0035578 azurophil granule lumen
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0044297 cell body
GO:0045121 membrane raft
GO:0045171 intercellular bridge
GO:0070062 extracellular exosome
GO:0072686 mitotic spindle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t42, PDBe:8t42, PDBj:8t42
PDBsum8t42
PubMed38658656
UniProtP07437|TBB5_HUMAN Tubulin beta chain (Gene Name=TUBB)

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