Structure of PDB 8stw Chain E

Receptor sequence
>8stwE (length=351) Species: 9606 (Homo sapiens) [Search protein sequence]
MRPDAPSRCTWQLGRPSPHHHTAPAKSPKILPDILKKIGDTPMVRINKIG
KKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPT
SGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNAR
FDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDG
KLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQT
EQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLC
GGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTNFLSDRWMLQKGF
L
3D structure
PDB8stw Disease-causing cystathionine beta-synthase linker mutations impair allosteric regulation.
ChainE
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.22: cystathionine beta-synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP E K119 N149 V255 G256 T257 G258 T260 G305 S349 P375 D376 K73 N103 V209 G210 T211 G212 T214 G259 S303 P329 D330
BS02 HEM E R51 C52 T53 W54 R58 S63 P64 H65 A226 L230 Y233 R266 R8 C9 T10 W11 R15 S17 P18 H19 A180 L184 Y187 R220
Gene Ontology
Molecular Function
GO:0004122 cystathionine beta-synthase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0019343 cysteine biosynthetic process via cystathionine
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:8stw, PDBe:8stw, PDBj:8stw
PDBsum8stw
PubMed37949228
UniProtP35520|CBS_HUMAN Cystathionine beta-synthase (Gene Name=CBS)

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