Structure of PDB 8smr Chain E

Receptor sequence

>8smrE (length=468) Species: 287 (Pseudomonas aeruginosa)

PAYNYKVVRQFAIMTVVWGVIGMGLGVLIASQLVWPQMNFDLPWTSFGRL
RPLHTNLVIFAFGGCALFATSYYTVQRTCQVRLFSDTLAAFTFWGWQAVA
VILLVSLPLGNTTTKEYAEIEFTGAIWLAIVWVAYAVVFFGTLIKRKVKH
IYVGNWFFGSFILTTAMLHIVNHMSLPVSWFKSYSMYSGATDAMVQWWYG
HNAVGFFLTTGFLGMMYYFVPKQAGRPVYSYRLSIVHFWALITLYIWAGP
HHLHYTALPDWAQSLGMVMSLILLAPSWGGMINGMMTLSGAWHKLRDDPI
LRFLVVSLAFYGMSTFEGPMMAIKTVNALSHYTDWTIGHVHAGALGWVAM
ITIGSLYHLIPKVYGVEKMHSVGLINAHFWLATIGTVLYIASLWVNGITQ
GLMWRAVNEDGTLTYSFVESLVASHPGFIVRLVGGGFFLTGMLLMSYNTW
RTVRQARPEGILAAARMA

3D structure

• PDB: 8smr Structure of the bc 1 - cbb 3 respiratory supercomplex from Pseudomonas aeruginosa.
• Chain: E
• Resolution: 2.7 Å

Enzymatic activity

• Enzyme Commision number: 7.1.1.9: cytochrome-c oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CU	E	H208 H258 H259	H201 H251 H252
BS02	HEM	E	G33 V34 I36 R58 H61 T62 V65 I66 Y124 I344 V347 H348 A351 L352 Y396 R438 G442	G26 V27 I29 R51 H54 T55 V58 I59 Y117 I337 V340 H341 A344 L345 Y389 R431 G435
BS03	HEM	E	Y124 W204 V211 L215 H258 H259 L280 G325 P326 M328 A329 H338 H346 V347 G350	Y117 W197 V204 L208 H251 H252 L273 G318 P319 M321 A322 H331 H339 V340 G343

Gene Ontology

Molecular Function

• GO:0004129 cytochrome-c oxidase activity
• GO:0020037 heme binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006119 oxidative phosphorylation
• GO:0009060 aerobic respiration
• GO:0015990 electron transport coupled proton transport
• GO:0022904 respiratory electron transport chain

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:8smr, PDBe:8smr, PDBj:8smr
• PDBsum: 8smr
• PubMed: 37751552
• UniProt: Q9HWP8