Structure of PDB 8sha Chain E

Receptor sequence
>8shaE (length=529) Species: 9606 (Homo sapiens) [Search protein sequence]
AFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGL
DKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTT
GVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLV
DIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFE
LIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEP
PKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFD
DEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAG
LVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALC
VIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRAFADALEV
IPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVI
ETLIGKKQQISLATQMVRMILKIDDIRKP
3D structure
PDB8sha Visualizing the chaperone-mediated folding trajectory of the G protein beta 5 beta-propeller structure
ChainE
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E L52 G53 P54 G105 T107 S175 G421 G422 C493 V506 E508 L45 G46 P47 G98 T100 S168 G414 G415 C486 V499 E501
BS02 AF3 E D73 D104 T106 K176 D404 D66 D97 T99 K169 D397
Gene Ontology
Molecular Function
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0031681 G-protein beta-subunit binding
GO:0044183 protein folding chaperone
GO:0048027 mRNA 5'-UTR binding
GO:0048487 beta-tubulin binding
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0007339 binding of sperm to zona pellucida
GO:0009615 response to virus
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0050821 protein stabilization
GO:0051086 chaperone mediated protein folding independent of cofactor
GO:0061077 chaperone-mediated protein folding
GO:1904871 positive regulation of protein localization to Cajal body
GO:1904874 positive regulation of telomerase RNA localization to Cajal body
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0044297 cell body
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8sha, PDBe:8sha, PDBj:8sha
PDBsum8sha
PubMed37852256
UniProtP48643|TCPE_HUMAN T-complex protein 1 subunit epsilon (Gene Name=CCT5)

[Back to BioLiP]