Structure of PDB 8s9v Chain E

Receptor sequence

>8s9vE (length=678) Species: 1148 (Synechocystis sp. PCC 6803)

SNFHNPYNFVPALPRDGITGDLGDCAPAGHSYYHGDKYSGRIAVKLTTVT
PLLIPDASKEEINNNHKTYPVRIGKDGKPYLPPTSIKGMLRSAYEAVTNS
RLAVFEDHDSRLAYRMPATMGLQMVPARIEGDNIVLYPGTSRIGNNGRPA
NNDPMYAAWLPYYQNRIAYQMAEHGDHVRFWAERYTRGNFCYWRVRQIAR
HNQNLGNRPERGRNYGQHHSTGVIEQFEGFVYKTNKNIGNKHDERVFIID
RESIEIPLSRDLRRKWRELITSYQEIHKKEVDRGDTGPSAVNGAVWSRQI
IADESERNLSDGTLCYAHVKKEDGQYKILNLYPVMITRGLYEIAPVDLLD
ETLKPATDKKQLSPADRVFGWVNQRGNGCYKGQLRIHSVTCQHDDAIDDF
GNQNFSVPLAILGQPKPEQARFYCADDRKGIPLEDGYDRDDGYSDSEQGL
RGRKVYPHHKGLPNGYWSNPTEDRSQQAIQGHYQEYRRPKKDGLEQRDDQ
NRSVKGWVKPLTEFTFEIDVTNLSEVELGALLWLLTLPDLHFHRLGGGKP
LGFGSVRLDIDPDKTDLRNGAGWRDYYGSLLETSQPDFTTLISQWINAFQ
TAVKEEYGSSSFDQVTFIKASGQSLQGFHDNASIHYPRSTPEPKPDGEAF
KWFVANEKGRRLALPALEKSQSFPIKPS

3D structure

• PDB: 8s9v RNA targeting and cleavage by the type III-Dv CRISPR effector complex.
• Chain: E
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	E	P166 A168 S196 K198 G199 R202 R226 W270 F307 T351 N354 I355 N357 K358 H359 R362 Y390 H394 S414 V451 M452 I453 R455 G487 W488 V489 C496 Y497 I528 L529 G530 Q531 P532 K533 Q536 Y540 K571 Y573 R619 G663 G664 G665 K666 P667 Y753 F767 F770	P55 A57 S85 K87 G88 R91 R115 W159 F190 T234 N237 I238 N240 K241 H242 R245 Y273 H277 S297 V334 M335 I336 R338 G370 W371 V372 C379 Y380 I411 L412 G413 Q414 P415 K416 Q419 Y423 K454 Y456 R502 G546 G547 G548 K549 P550 Y636 F650 F653
BS02	rna	E	A229 L233 N357 K396 S406 A407 V489 N490 Q491 G493 N494 Q617 E765 F767 K775	A118 L122 N240 K279 S289 A290 V372 N373 Q374 G376 N377 Q500 E648 F650 K658

Gene Ontology

Biological Process

• GO:0051607 defense response to virus

External links

• PDB: RCSB:8s9v, PDBe:8s9v, PDBj:8s9v
• PDBsum: 8s9v
• PubMed: 38637512
• UniProt: Q6ZED5