Structure of PDB 8rh8 Chain E

Receptor sequence

>8rh8E (length=329) Species: 9606 (Homo sapiens) [Search protein sequence]

LLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHY
WKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVM
LRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLM
LYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTL
RRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTI
ITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQ
DTHAIDKYSRIIFPAAYILFNLIYWSIFS

3D structure

PDB

8rh8 Divergent mechanisms of steroid inhibition in the human rho1 GABAA receptor

Chain

Resolution

2.66 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ABU	E	F159 E217 Y262	F82 E140 Y185
BS02	ABU	E	Y123 R125	Y46 R48

External links

PDB	RCSB:8rh8, PDBe:8rh8, PDBj:8rh8
PDBsum	8rh8
PubMed
UniProt	P24046\|GBRR1_HUMAN Gamma-aminobutyric acid receptor subunit rho-1 (Gene Name=GABRR1)

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