Structure of PDB 8rh4 Chain E

Receptor sequence

>8rh4E (length=332) Species: 9606 (Homo sapiens) [Search protein sequence]

SEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYL
RHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTD
NVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTED
DLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYIN
FTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTM
STIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQER
KEQDTHAIDKYSRIIFPAAYILFNLIYWSIFS

3D structure

PDB

8rh4 Divergent mechanisms of steroid inhibition in the human rho1 GABAA receptor

Chain

Resolution

2.52 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	EST	E	N332 R337 S339	N258 R263 S265
BS02	EST	E	S334 P336	S260 P262

External links

PDB	RCSB:8rh4, PDBe:8rh4, PDBj:8rh4
PDBsum	8rh4
PubMed
UniProt	P24046\|GBRR1_HUMAN Gamma-aminobutyric acid receptor subunit rho-1 (Gene Name=GABRR1)

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