Structure of PDB 8rcf Chain E

Receptor sequence

>8rcfE (length=311) Species: 9606 (Homo sapiens) [Search protein sequence]

GPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAK
ADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETG
SITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPER
LLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLI
VDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVV
AQVDPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFA
INADGVGDAKD

3D structure

PDB

8rcf RAD51 protects abasic sites to prevent replication fork breakage.

Chain

Resolution

3.4 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	E	R229 L238 R241 Q242 V270 A271 V273 G289	R209 L218 R221 Q222 V250 A251 V253 G261
BS02	ATP	E	R130 T131 G132 K133 T134 Q135 R170 I329 N330	R110 T111 G112 K113 T114 Q115 R150 I301 N302
BS03	CA	E	A293 H294 S296 D316	A265 H266 S268 D288
BS04	ATP	E	H294 S317 P318 C319 L320 P321	H266 S289 P290 C291 L292 P293

External links

PDB	RCSB:8rcf, PDBe:8rcf, PDBj:8rcf
PDBsum	8rcf
PubMed	39178838
UniProt	Q06609\|RAD51_HUMAN DNA repair protein RAD51 homolog 1 (Gene Name=RAD51)

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