Structure of PDB 8qki Chain E

Receptor sequence

>8qkiE (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]

MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSS
FICNTLQPGCNSVCYDQFFPISHVRLWSLQLILVSTPALLVAMHVAHQQH
IEKKMLRLRHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAMV
RLVKCDVYPCPNTVDCFVSRPTEKTVFTVFMLAASGICIILNVAEVVYLI
IRACARR

3D structure

PDB

8qki Two distinct mechanisms of connexin channel inhibition by mefloquine and 2-aminoethoxydiphenyl borate

Chain

Resolution

3.46 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CLR	E	L9 L10 L25 F29 S85 A88	L9 L10 L25 F29 S85 A88

External links

PDB	RCSB:8qki, PDBe:8qki, PDBj:8qki
PDBsum	8qki
PubMed
UniProt	P08034\|CXB1_HUMAN Gap junction beta-1 protein (Gene Name=GJB1)

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