Structure of PDB 8qk6 Chain E

Receptor sequence

>8qk6E (length=205) Species: 9606 (Homo sapiens) [Search protein sequence]

MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSS
FICNTLQPGCNSVCYDQFFPISHVRLWSLQLILVSTPALLVAMHVAHQQH
IEKKMRHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAMVRLV
KCDVYPCPNTVDCFVSRPTEKTVFTVFMLAASGICIILNVAEVVYLIIRA
CARRA

3D structure

PDB

8qk6 Two distinct mechanisms of connexin channel inhibition by mefloquine and 2-aminoethoxydiphenyl borate

Chain

Resolution

3.18 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CLR	E	W3 L6	W3 L6
BS02	CLR	E	L9 L10	L9 L10

External links

PDB	RCSB:8qk6, PDBe:8qk6, PDBj:8qk6
PDBsum	8qk6
PubMed
UniProt	P08034\|CXB1_HUMAN Gap junction beta-1 protein (Gene Name=GJB1)

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