Structure of PDB 8qch Chain E

Receptor sequence
>8qchE (length=344) Species: 9606 (Homo sapiens) [Search protein sequence]
TDFYSELPKVELHAHLNGSISSHTMKKLIAQKPDLKIHDQMTVIDKGKKR
TLEECFQMFQTIHQLTSSPEDILMVTKDVIKEFADDGVKYLELRSTPRRE
NATGMTKKTYVESILEGIKQSKQENLDIDVRYLIAVDRRGGPLVAKETVK
LAEEFFLSTEGTVLGLDLSGDPTVGQAKDFLEPLLEAKKAGLKLALHLSE
IPNQKKETQILLDLLPDRIGHGTFLNSGEGGSLDLVDFVRQHRIPLELCL
TSNVKSQTVPSYDQHHFGFWYSIAHPSVICTDDKGVFATHLSQEYQLAAE
TFNLTQSQVWDLSYESINYIFASDSTRSELRKKWNHLKPRVLHI
3D structure
PDB8qch The activation chain of the broad-spectrum antiviral bemnifosbuvir at atomic resolution
ChainE
Resolution2.442 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EIF E H26 L27 N28 F67 F70 H74 S106 T107 G181 H208 E211 D294 H15 L16 N17 F56 F59 H63 S95 T96 G170 H197 E200 D283
BS02 ZN E H24 H26 H208 D293 H13 H15 H197 D282
Gene Ontology
Molecular Function
GO:0004000 adenosine deaminase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0062154 N6-methyl-AMP deaminase activity
Biological Process
GO:0006154 adenosine catabolic process
GO:0009117 nucleotide metabolic process
GO:0046103 inosine biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:8qch, PDBe:8qch, PDBj:8qch
PDBsum8qch
PubMed39190717
UniProtQ6DHV7|ADAL_HUMAN Adenosine deaminase-like protein (Gene Name=ADAL)

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