Structure of PDB 8q7e Chain E

Receptor sequence
>8q7eE (length=937) Species: 9606 (Homo sapiens) [Search protein sequence]
LMVPLRLQAYPEELIRQRHDGHPEYLIRWSVLKCEHILMWLSAPEVYANC
PGLLDEVAMGEMEADVQALVRRAARQSLTAAVLHTIHVLSAYASIGPLTG
VFRETGALDLLMHMLCNPEPQIRRSAGKMLQALAAHDAGSRAHVLLSLSQ
QHMDFDSRYTLLELFAETTSSEEHCMAFEGIHLPQIPGKLLFSLVKRYLC
VTSLLDQLNSRGQRELEFSMAVGNLISELVRSMGWARPTRSIFQPLYPLP
YLQPTQAEWWELLFFIKKLDLCEQQPIFQNLWKNLGEISVSVEMAESLLQ
VLSSRFEGSTLNDLLNSQIYTKYLSVLRVITRLLDFPELPWHEVLEPCLN
CLSDSEIVQELTCFLHRLASHKDYAVVLCCLGAKEILSKVLDKHGCELRD
LVTECEKYAQLYSNLTSSILAGCIQMVLGQIEDHRRTHQPINIPFFDVFL
RHLCQFWPLFREQLCRRTCLFYTIRAQAWSRDIAEDHRRLLQLCPRLNRV
LRHEQNFADRFLPDDEAAQALGKTCWEALVSPLVQNITSPDAEGVSALGW
LLDQYLEQRETSRNPLSRAASFASRVRRLCHLLVHVEPPSSSLRNITQCW
LSVVQEQVSRFLAAAWRAPDFVPRYCKLYEHLQRAGSELFGPRAAFMLAL
RSGFSGALLQQSFLTAAHMSEQFARYIDQQIQGGLIGGAPGVEMLGQLQR
HLEPIMVLSGLELATTFEHFYQHYMADRLLSFSWLEGAVLEQIGLCFPNR
LPQLMLQSLSTSEELQRQFHLFQLQRLDKLFLEQEDEPSPAISILVLSPR
CWPVSPLCYLYHPRKCLPTEFCDALDRFSSFYSQSQNHRRLQWTWLGRAE
LQFGKQILHVSTVQMWLLLKFNQTEEVSVETLLKDSDLSPELLLQALVPL
TSGNGPLTLHEGVLRLHEPGSGEALWLIPPQAYLNVE
3D structure
PDB8q7e Noncanonical assembly, neddylation and chimeric cullin RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex
ChainE
Resolution4.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E A1694 I1695 S1696 L1698 L1700 Q1753 T1755 E1761 L1762 A791 I792 S793 L795 L797 Q842 T844 E850 L851
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007088 regulation of mitotic nuclear division
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031461 cullin-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8q7e, PDBe:8q7e, PDBj:8q7e
PDBsum8q7e
PubMed38605244
UniProtQ8IWT3|CUL9_HUMAN Cullin-9 (Gene Name=CUL9)

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