Structure of PDB 8poh Chain E

Receptor sequence
>8pohE (length=515) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))) [Search protein sequence]
EERFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSK
EVNARIEPFLRTTPRPLRLPDGPPCSQRSKFLLMDALALSIEDPSHEGEG
IPLYDAIKCMKTFFGWKEPNIIKPHEKGINPNYLLTWKQVLAELQDIENE
EKIPRTKNMKKTSQLKWALGENMAPEKVDFEDCKDVNDLKQYDSDEPEPR
SLACWIQSEFNKACELTDSSWVELDEIGEDVAPIEHIASMRRNYFTAEVS
HCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKRRTKEGRRKTNLY
GFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLR
TAVGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESS
VKEKDLTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYA
SPQLEGFSAESRKLLLIVQALRDNLEPGTFDLEGLYEAIEECLINDPWVL
LNASWFNSFLTHALR
3D structure
PDB8poh The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
ChainE
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna E H510 L511 R512 H309 L310 R311
BS02 rna E K328 G371 N373 M374 A375 Y393 S395 E397 R508 H510 V517 R566 T567 N568 K574 K127 G170 N172 M173 A174 Y192 S194 E196 R307 H309 V316 R365 T366 N367 K373
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8poh, PDBe:8poh, PDBj:8poh
PDBsum8poh
PubMed38316757
UniProtM9TI86

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