Structure of PDB 8p2h Chain E

Receptor sequence

>8p2hE (length=669) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence]

MAREFSLEKTRNIGIMAHIDAGKTTTTERILYYTGRIITITSAATTAAWE
GHRVNIIDTPGHVDFTVEVERSLRVLDGAVTVLDAQSGVEPQTETVWRQA
TTYGVPRIVFVNKMDKLGANFEYSVSTLHDRLQANAAPIQLPIGAEDEFE
AIIDLVEMKCFKYTNDLGTEIEEIEIPEDHLDRAEEARASLIEAVAETSD
ELMEKYLGDEEISVSELKEAIRQATTNVEFYPVLCGTAFKNKGVQLMLDA
VIDYLPSPLDVKPIIGHRASNPEEEVIAKADDSAEFAALAFKVMTDPYVG
KLTFFRVYSGTMTSGSYVKNSTKGKRERVGRLLQMHANSRQEIDTVYSGD
IAAAVGLKDTGTGDTLCGEKNDIILESMEFPEPVIHLSVEPKSKADQDKM
TQALVKLQEEDPTFHAHTDEETGQVIIGGMGELHLDILVDRMKKEFNVEC
NVGAPMVSYRETFKSSAQVQGKFSRQSGGRGQYGDVHIEFTPNETGAGFE
FENAIVGGVVPREYIPSVEAGLKDAMENGVLAGYPLIDVKAKLYDGSYHD
VDSSEMAFKIAASLALKEAAKKCDPVILEPMMKVTIEMPEEYMGDIMGDV
TSRRGRVDGMEPRGNAQVVNAYVPLSEMFGYATSLRSNTQGRGTYTMYFD
HYAEVPKSIAEDIIKKNKG

3D structure

PDB

8p2h Staphylococcus aureus 70S ribosome with elongation factor G locked with fusidic acid with a tRNA in pe/E chimeric hybrid state

Chain

Resolution

2.49 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	E	H18 I19 H85 R498 K582 I583 S586 M616 G617 M620 T624 S625 V630 D631 R659 S660 Q663	H18 I19 H62 R475 K559 I560 S563 M593 G594 M597 T601 S602 V607 D608 R636 S637 Q640
BS02	rna	E	Y321 G323 Y340 R349 R351 G353 R354 R498 G501 R503 G530 R535	Y298 G300 Y317 R326 R328 G330 R331 R475 G478 R480 G507 R512
BS03	GDP	E	D20 G22 K23 T24 T25 N135 K136 D138 T260 F262	D20 G22 K23 T24 T25 N112 K113 D115 T237 F239
BS04	FUA	E	P83 F88 E91 D434 I460 L461 R464	P60 F65 E68 D411 I437 L438 R441

Gene Ontology

	Molecular Function
GO:0003746	translation elongation factor activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

	Biological Process
GO:0006412	translation
GO:0006414	translational elongation
GO:0032790	ribosome disassembly

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8p2h, PDBe:8p2h, PDBj:8p2h
PDBsum	8p2h
PubMed	38902339
UniProt	Q2G0N1\|EFG_STAA8 Elongation factor G (Gene Name=fusA)

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