Structure of PDB 8p2f Chain E

Receptor sequence

>8p2fE (length=670) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325) [Search protein sequence]

MAREFSLEKTRNIGIMAHIDAGKTTTTERILYYTGRIGITITSAATTAAW
EGHRVNIIDTPGHVDFTVEVERSLRVLDGAVTVLDAQSGVEPQTETVWRQ
ATTYGVPRIVFVNKMDKLGANFEYSVSTLHDRLQANAAPIQLPIGAEDEF
EAIIDLVEMKCFKYTNDLGTEIEEIEIPEDHLDRAEEARASLIEAVAETS
DELMEKYLGDEEISVSELKEAIRQATTNVEFYPVLCGTAFKNKGVQLMLD
AVIDYLPSPLDVKPIIGHRASNPEEEVIAKADDSAEFAALAFKVMTDPYV
GKLTFFRVYSGTMTSGSYVKNSTKGKRERVGRLLQMHANSRQEIDTVYSG
DIAAAVGLKDTGTGDTLCGEKNDIILESMEFPEPVIHLSVEPKSKADQDK
MTQALVKLQEEDPTFHAHTDEETGQVIIGGMGELHLDILVDRMKKEFNVE
CNVGAPMVSYRETFKSSAQVQGKFSRQSGGRGQYGDVHIEFTPNETGAGF
EFENAIVGGVVPREYIPSVEAGLKDAMENGVLAGYPLIDVKAKLYDGSYH
DVDSSEMAFKIAASLALKEAAKKCDPVILEPMMKVTIEMPEEYMGDIMGD
VTSRRGRVDGMEPRGNAQVVNAYVPLSEMFGYATSLRSNTQGRGTYTMYF
DHYAEVPKSIAEDIIKKNKG

3D structure

PDB

8p2f Cryo-EM structures of Staphylococcus aureus 70S ribosomes in complex with elongation factor G and fusidic acid

Chain

Resolution

2.44 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	E	H18 H85 R498 M616 G617 M620 V630 D631 R659 S660 Q663	H18 H63 R476 M594 G595 M598 V608 D609 R637 S638 Q641
BS02	rna	E	Q499 S500 G502 H572	Q477 S478 G480 H550
BS03	rna	E	Y340 R349 R351 G353 R354 K381 R498 S500	Y318 R327 R329 G331 R332 K359 R476 S478
BS04	rna	E	G502 R503	G480 R481
BS05	GDP	E	D20 G22 K23 T24 T25 N135 K136 D138 T260 F262	D20 G22 K23 T24 T25 N113 K114 D116 T238 F240
BS06	WUX	E	P83 F88 E91 I460 L461 R464	P61 F66 E69 I438 L439 R442

Gene Ontology

	Molecular Function
GO:0003746	translation elongation factor activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

	Biological Process
GO:0006412	translation
GO:0006414	translational elongation
GO:0032790	ribosome disassembly

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8p2f, PDBe:8p2f, PDBj:8p2f
PDBsum	8p2f
PubMed	38902339
UniProt	Q2G0N1\|EFG_STAA8 Elongation factor G (Gene Name=fusA)

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