Structure of PDB 8ovf Chain E

Receptor sequence
>8ovfE (length=777) Species: 9606 (Homo sapiens) [Search protein sequence]
HLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDD
SNESDVVESLDEIFHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEM
VEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQ
RVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFEL
SKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFR
ERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGK
YSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFY
GPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGK
IIQCLKKTKTENPLILIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDH
YLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAER
YLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLRK
SAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWTA
MGGSTLFVETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFAR
AFLMQHAPANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRP
VRQNLAMTGEVSLTGKILPVGGIKEKTIAAKRAGVTCIVLPAENKKDFYD
LAAFITEGLEVHFVEHYREIFDIAFPD
3D structure
PDB8ovf Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions.
ChainE
Resolution7.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.53: endopeptidase La.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E H491 P524 P525 G526 V527 G528 K529 T530 Y661 I669 Y673 R710 H319 P352 P353 G354 V355 G356 K357 T358 Y489 I497 Y501 R538
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006508 proteolysis
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
GO:0030163 protein catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8ovf, PDBe:8ovf, PDBj:8ovf
PDBsum8ovf
PubMed38688959
UniProtP36776|LONM_HUMAN Lon protease homolog, mitochondrial (Gene Name=LONP1)

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