Structure of PDB 8oka Chain E

Receptor sequence

>8okaE (length=777) Species: 9606 (Homo sapiens)

HLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDD
SNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEM
VEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQ
RVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFEL
SKLQQRLGREVEEKIKQTHRKFLLQEQLKIIKKELGLEKDDKDAIEEKFR
ERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGK
YSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFY
GPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGK
IIQCLKKTKTENPLILIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDH
YLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAER
YLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLRK
SAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWTA
MGGSTLFVETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFAR
AFLMQHAPANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRP
VRQNLAMTGEVSLTGKILPVGGIKEKTIAAKRAGVTCIVLPAENKKDFYD
LAAFITEGLEVHFVEHYREIFDIAFPD

3D structure

• PDB: 8oka Phosphorylation of the N-terminal domain of human mitochondrial Lon protease disrupts its functions
• Chain: E
• Resolution: 3.89 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.53: endopeptidase La.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	E	H491 P525 V527 G528 K529 T530 Y661 I669 Y673 R710	H319 P353 V355 G356 K357 T358 Y489 I497 Y501 R538

Gene Ontology

Molecular Function

• GO:0004176 ATP-dependent peptidase activity
• GO:0004252 serine-type endopeptidase activity
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0006508 proteolysis
• GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
• GO:0030163 protein catabolic process

External links

• PDB: RCSB:8oka, PDBe:8oka, PDBj:8oka
• PDBsum: 8oka
• PubMed: 38688959
• UniProt: P36776|LONM_HUMAN Lon protease homolog, mitochondrial (Gene Name=LONP1)