Structure of PDB 8oh5 Chain E

Receptor sequence

>8oh5E (length=584) Species: 1123288 (Sporomusa ovata DSM 2662)

MKVRVGLGSCGIAAGGRKVMDRLAQEIKNHGKEIELLPTGCIGMCFYEPI
VDVFDGDKVYSYANVTADMATEIFNSHIIGGQPLTQYIVSTTEKPYTILA
KQVRIALRNCGVIDPENVDEYKANDGYKALSKALKEMTPEEVIEEIKVAG
LRGRGGAGFPTWFKWNAARQSKGEIKYVVCNADEGDPGAFMDRSVLEGDP
HALLEGMAICGYAIGANEGHIYCRAEYPLAIKRLEIAIADAKQRNLLGKN
IMGTNFSFDMKIKKGAGAFVCGEETALIASLEGERGMPRLKPPFPAQSGF
WGKPTNINNVETFANVPWIMYNGGSAYAAYGTEKSKGTKVFALAGKIKNG
GLVEVPMGMSLREVIYDIGGGILNDREFKAVQMGGPSGGCIPKQLLDTPV
DYDSINKTGAIMGSGGMIVMDETTCMVDMARFFLDFTVKESCGKCIYCRI
GTKRMLEILERITTGEGREGDIEELEELSISIKDGSLCGLGQTAPNPVLT
TIRYFRDEYEAHIRDKKCPAKSCKPLLTYTINQDNCKGCTLCAQKCPVQA
ITGEKKKPHVIDQALCTKCGNCASVCRLDAVCIE

3D structure

• PDB: 8oh5 Molecular architecture and electron transfer pathway of the Stn family transhydrogenase.
• Chain: E
• Resolution: 3.0 Å

Enzymatic activity

• Enzyme Commision number: 1.12.1.2: hydrogen dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	E	C425 H512 C518 C523	C425 H512 C518 C523
BS02	FES	E	C10 C41 C45	C10 C41 C45
BS03	FMN	E	R154 K164 N181 F269 E273 E274 I307 N308 N309 G489 L490	R154 K164 N181 F269 E273 E274 I307 N308 N309 G489 L490
BS04	SF4	E	C546 P547 V548 C566 T567 K568 C569 C572	C546 P547 V548 C566 T567 K568 C569 C572
BS05	SF4	E	I531 C536 T540 C542 H559	I531 C536 T540 C542 H559
BS06	NAD	E	G155 G156 F159 F163 E273 E274 K291 F294 G413	G155 G156 F159 F163 E273 E274 K291 F294 G413
BS07	SF4	E	P288 C442 G443 C445 C448 C488 L490 G491	P288 C442 G443 C445 C448 C488 L490 G491

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0047985 hydrogen dehydrogenase activity
• GO:0051539 4 iron, 4 sulfur cluster binding

External links

• PDB: RCSB:8oh5, PDBe:8oh5, PDBj:8oh5
• PDBsum: 8oh5
• PubMed: 37673911
• UniProt: A0A0U1KYM9