Structure of PDB 8jwn Chain E

Receptor sequence
>8jwnE (length=329) Species: 1038928 (Streptomyces xinghaiensis) [Search protein sequence]
MEYTQLGRIGLKVSRLVLGTMNFGPTTDEAESHAIMDAALDAGINFFDTA
NVYGWGENKGRTEEILGSWFAQGGDRRDKVVLATKVYGNMGDGPAWPNHD
KLSALNIRRSVDASLKRLGTDHIDLYQFHHVDRDTPWDEIWQAMDVLVRQ
GKILYVGSSNFAGWNIAQANETAARHGRLGLVSEQCLYNLCERRAEMEVV
PAAREYGLGVIAWSPLHGGLLGGAIRKEQEGNRRAASGRAADALKDPQQR
EQIQRYEDLLDKHGLEPGEVALAWLLTRPGVTGPIVGPRTADQLASAVRA
AELTLTDEVLTALDEIFPGPGPSPEAFAW
3D structure
PDB8jwn A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D.
ChainE
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP E G19 M21 D48 Y53 Q186 W214 S215 P216 L217 G219 G220 R235 R236 A237 I287 G289 R291 Q295 S298 G19 M21 D48 Y53 Q185 W213 S214 P215 L216 G218 G219 R233 R234 A235 I285 G287 R289 Q293 S296
BS02 NDP E M21 Y53 W55 H130 G240 R241 M21 Y53 W55 H129 G238 R239
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:8jwn, PDBe:8jwn, PDBj:8jwn
PDBsum8jwn
PubMed38459030
UniProtA0A3R7J519

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