Structure of PDB 8jnk Chain E

Receptor sequence
>8jnkE (length=203) Species: 9606 (Homo sapiens) [Search protein sequence]
RVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLSQDVPWKQRT
YQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNSL
LCNLYRNEKDSVDWHSDDCPSLGRSPIIASLSFGATRTFEMRKKPPPEEN
GDYTYVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRT
VYP
3D structure
PDB8jnk The Molecular Basis of Human ALKBH3 Mediated RNA N1-methyladenosine (m1A) Demethylation
ChainE
Resolution2.69 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.33: DNA oxidative demethylase.
1.14.11.54: mRNA N(1)-methyladenine demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E Y127 P130 R131 Y143 S144 V188 D189 H191 D193 D194 C195 K261 Y51 P54 R55 Y67 S68 V112 D113 H115 D117 D118 C119 K185
BS02 MN E H191 D193 H257 H115 D117 H181
Gene Ontology
Molecular Function
GO:0051213 dioxygenase activity
Biological Process
GO:0006281 DNA repair
GO:0006307 DNA alkylation repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8jnk, PDBe:8jnk, PDBj:8jnk
PDBsum8jnk
PubMed38158383
UniProtQ96Q83|ALKB3_HUMAN Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (Gene Name=ALKBH3)

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