Structure of PDB 8it0 Chain E

Receptor sequence
>8it0E (length=465) Species: 1393122 (Thermoflavifilum thermophilum) [Search protein sequence]
MKELIYIEEPSILFAHGQKCTDPRDGLALFGPLNQIYGIKSGVVGTQKGL
QIFKSYLDKIQKPIYNHNNITRPMFPGFEAVFGCKWESQNIVFKEITDEE
IRRYLFNASTHKRTYDLVTLFNDKIITANKNDEERVDVWFVIVPEEIYKY
CRPNSVLYNYDAQFHDQLKARLLEHTIPTQILRESTLAWRDFKNTFGAPI
RDFSKIEGHLAWTISTAAYYKAGGKPWKLGDIRPGVCYLGLVYKKIEKSK
NPQNACCAAQMFLDNGDGTVFKGEVGPWYNPEKGEYHLKPKEAKALLTQA
LESYKEQNKSYPKEVFIHARTRFNDEEWNAFNEVTPKNTNLVGVTITKSK
PLKLYKTEGAFPIMRGNAYIVDEKKAFLWTLGFVPKLQSTLSMEVPNPIF
IEINKGEAEIQQVLKDILALTKLNYNACIYADGEPVTLRFANKIGEILTA
STEIKTPPLAFKYYI
3D structure
PDB8it0 Nucleic acid-triggered NADase activation of a short prokaryotic Argonaute.
ChainE
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E K286 K287 E289 R362 K244 K245 E247 R320
BS02 rna E E324 K325 L423 N439 E282 K283 L381 N397
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding

View graph for
Molecular Function
External links
PDB RCSB:8it0, PDBe:8it0, PDBj:8it0
PDBsum8it0
PubMed37783228
UniProtA0A1I7NFD7

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