Structure of PDB 8iau Chain E

Receptor sequence
>8iauE (length=499) Species: 171101 (Streptococcus pneumoniae R6) [Search protein sequence]
NKRVKIVATLGPAVEIRGGKKFGEDGYWGEKLDVEASAKNIAKLIEAGAN
TFRFNFSHGDHQEQGERMATVKLAEKIAGKKVGFLLDTKGPEIRTELFEG
EAKEYSYKTGEKIRVATKQGIKSTREVIALNVAGALDIYDDVEVGRQVLV
DDGKLGLRVVAKDDATREFEVEVENDGIIAKQKGVNIPNTKIPFPALAER
DNDDIRFGLEQGINFIAISFVRTAKDVNEVRAICEETGNGHVQLFAKIEN
QQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIIKKVNAAGKV
VITATNMLETMTEKPRATRSEVSDVFNAVIDGTDATMLSGESANGKYPLE
SVTTMATIDKNAQALLNEYGRLDSDSFERNSKTEVMASAVKDATSSMDIK
LVVTLTKTGHTARLISKYRPNADILALTFDELTERGLMLNWGVIPMLTDA
PSSTDDMFEIAERKAVEAGLVESGDDIVIVAGVPVGEAVRTNTMRIRTV
3D structure
PDB8iau Functional and structural characterization of Streptococcus pneumoniae pyruvate kinase involved in fosfomycin resistance.
ChainE
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FBP E S382 T384 T407 K408 T409 H411 T412 V490 R491 S381 T383 T406 K407 T408 H410 T411 V489 R490
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iau, PDBe:8iau, PDBj:8iau
PDBsum8iau
PubMed37286036
UniProtQ8DQ84

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