Structure of PDB 8i6v Chain E

Receptor sequence
>8i6vE (length=611) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
MKFGEHLSKSLIRQYSYYYISYDDLKTELEDNLSKNNGQWTQELETDFLE
SLEIELDKVYTFCKVKHSEVFRRVKEVQEQVQHTVRLLDSNNPPTQLDFE
ILEEELSDIIADVHDLAKFSRLNYTGFQKIIKKHDKKTGFILKPVFQVRL
DSKPFFKENYDELVVKISQLYDIARTSGRPNFVRQTTKYWVHPDNITELK
LIILKHLPVLVFNTNKEFEREDSAITSIYFDNENLDLYYGRLRKDEGAEA
HRLRWYGGMSTDTIFVERKTHREDWTGEKSVKARFALKERHVNDFLKGKY
TVDQVFAKMRKEGKKPMNEIENLEALASEIQYVMLKKKLRPVVRSFYNRT
AFQLPGDARVRISLDTELTMVREDNFDGVDRTHKNWRRTDIGVDWPFKQL
DDKDICRFPYAVLEVKLQTQLGQEPPEWVRELVGSHLVEPVPKFSKFIHG
VATLLNDKVDSIPFWLPQMDVDIRKPPLDFDEDDEDDAALVAAMTIRAPP
GKTICVPVRVEPKVYFATERTYLSWLSISILLGGVSTTLLTYGSPTAMIG
SIGFFITSLAVLIRTVMVYAKRVVNIRLKRAVDYEDKIGPGMVSVFLILS
ILFSFFCNLVA
3D structure
PDB8i6v Cryo-EM structure of the polyphosphate polymerase VTC reveals coupling of polymer synthesis to membrane transit.
ChainE
Resolution3.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.1: ATP-polyphosphate phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3PO E R264 R266 K458 R252 R254 K446
Gene Ontology
Molecular Function
GO:0000822 inositol hexakisphosphate binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0008976 polyphosphate kinase activity
GO:0016740 transferase activity
Biological Process
GO:0006797 polyphosphate metabolic process
GO:0006799 polyphosphate biosynthetic process
GO:0007034 vacuolar transport
GO:0016237 microautophagy
GO:0042144 vacuole fusion, non-autophagic
GO:0061736 engulfment of target by autophagosome
Cellular Component
GO:0000329 fungal-type vacuole membrane
GO:0000421 autophagosome membrane
GO:0005737 cytoplasm
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005938 cell cortex
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0033254 vacuolar transporter chaperone complex
GO:0071944 cell periphery

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i6v, PDBe:8i6v, PDBj:8i6v
PDBsum8i6v
PubMed37066886
UniProtP47075|VTC4_YEAST Vacuolar transporter chaperone complex subunit 4 (Gene Name=VTC4)

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