Structure of PDB 8hwb Chain E

Receptor sequence
>8hwbE (length=700) Species: 10244 (Monkeypox virus) [Search protein sequence]
MDAAIRGNDVIFVLKTIGVPSACRQNEDPRFVEAFKCDELERYIDNNPEC
TLFESLRDEEAYSIVRIFMDVDLDACLDEIDYLTAIQDFIIEVSNCVARF
AFTECGAIHENVIKSMRSNFSLTKSTNRDKTSFHIIFLDTYTTMDTLIAM
KRTLLELSRSSENPLTRSIDTAVYRRKTTLRVVGTRKNPNCDTIHVMQPP
HDNIEDYLFTYVDMNNNSYYFSLQRRLEDLVPDKLWEPGFISFEDAIKRV
SKIFINSIINFNDLDENNFTTVPLVIDYVTPCALCKKRSHKHPHQLSLEN
GAIRIYKTGNPHSCKVKIVPLDGNKLFNIAQRILDTNSVLLTERGDHIVW
INNSWKFNSEEPLITKLILSIRHQLPKEYSSELLCPRKRKTVEANIRDML
VDSVETDTYPDKLPFKNGVLDLVDGMFYSGDDAKKYTCTVSTGFKFDDTK
FVEDSPEMEELMNIINDIQPLTDENKKNRELYEKTLSSCLCGATKGCLTF
FFGETATGKSTTKRLLKSAIGDLFVETGQTILTDVLDKGPNPFIANMHLK
RSVFCSELPDFACSGSKKIRSDNIKKLTEPCVIGRPCFSNKINNRNHATI
IIDTNYKPVFDRIDNALMRRIAVVRFRTHFSQPSGREAAENNDAYDKVKL
LDEGLDGKIQNNRYRFAFLYLLVKWYKKYHIPIMKLYPTPEEIPDFAFYL
3D structure
PDB8hwb Structural insight into the assembly and working mechanism of helicase-primase D5 from Mpox virus.
ChainE
Resolution3.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E P540 R585 C587 F588 P540 R585 C587 F588
BS02 ADP E D467 A506 T507 G508 K509 S510 T511 F630 D652 L655 D656 D467 A506 T507 G508 K509 S510 T511 F630 D652 L655 D656
BS03 ATP E D70 H134 R175 K187 D70 H134 R175 K187
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Cellular Component
GO:0030430 host cell cytoplasm

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8hwb, PDBe:8hwb, PDBj:8hwb
PDBsum8hwb
PubMed38177671
UniProtA0A7H0DN89|PG117_MONPV Uncoating factor OPG117 (Gene Name=OPG117)

[Back to BioLiP]