Structure of PDB 8hpy Chain E

Receptor sequence
>8hpyE (length=515) Species: 9606 (Homo sapiens) [Search protein sequence]
KCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFT
PSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKS
LIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGH
TNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSID
TFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIV
IETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDIEILKIRKPNDIETFKI
ENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIVRT
PQTLRTPHLILSSSSQRPVIYQWNKATQLFTNQTDIPNMEDVYAVKHFSV
KGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYA
ILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASS
FKGNTQIYKHVIVDL
3D structure
PDB8hpy Crystal structure of human LGI1-ADAM22 complex
ChainE
Resolution5.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA E D334 E336 D381 V382 E383 D294 E296 D341 V342 E343
Gene Ontology
Molecular Function
GO:0005102 signaling receptor binding
GO:0005515 protein binding
Biological Process
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0030307 positive regulation of cell growth
GO:0031175 neuron projection development
GO:0050806 positive regulation of synaptic transmission
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0030425 dendrite
GO:0043083 synaptic cleft
GO:0043194 axon initial segment
GO:0045202 synapse
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8hpy, PDBe:8hpy, PDBj:8hpy
PDBsum8hpy
PubMed
UniProtO95970|LGI1_HUMAN Leucine-rich glioma-inactivated protein 1 (Gene Name=LGI1)

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