Structure of PDB 8h66 Chain E

Receptor sequence
>8h66E (length=160) Species: 9606 (Homo sapiens) [Search protein sequence]
GIIEFHVIGNSNRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTL
ALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEY
HIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLM
ECELNPRIPY
3D structure
PDB8h66 Molecular Basis of KAT2A Selecting Acyl-CoA Cofactors for Histone Modifications.
ChainE
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1VU E Q530 I576 V577 C579 A580 V581 Q586 V587 G589 G591 T592 Y617 A618 Y621 K624 Q29 I75 V76 C78 A79 V80 Q85 V86 G88 G90 T91 Y116 A117 Y120 K123
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

View graph for
Molecular Function
External links
PDB RCSB:8h66, PDBe:8h66, PDBj:8h66
PDBsum8h66
PubMed37040526
UniProtQ92830|KAT2A_HUMAN Histone acetyltransferase KAT2A (Gene Name=KAT2A)

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