Structure of PDB 8gwe Chain E

Receptor sequence
>8gweE (length=586) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
AVGACVLCNSQTSLRCGACIRRPFLCCKCCYDHVISTSHKLVLSVNPYVC
NAPGCDVTDVTQLYLGGMSYYCKSHKPPISFPLCANGQVFGLYKNTCVGS
DNVTDFNAIATCDWTNAGDYILANTCTERLKLFAAETLKATEETFKLSYG
IATVREVLSDRELHLSWEVGKPRPPLNRNYVFTGYRVTKNSKVQIGEYTF
EKGAVVYRGTTTYKLNVGDYFVLTSHTVMPLSAPTLVPQEHYVRITGLYP
TLNISDEFSSNVANYQKVGMQKYSTLQGPPGTGKSHFAIGLALYYPSARI
VYTACSHAAVDALCEKALKYLPIDKCSRIIPAVECFDKFKVNSTLEQYVF
CTVNALPETTADIVVFDEISMATNYDLSVVNARLRAKHYVYIGDPAQLPA
PRTLLTKGTLEPEYFNSVCRLMKTIGPDMFLGTCRRCPAEIVDTVSALVY
DNKLKAHKDKSAQCFKMFYKGVITHDVSSAINRPQIGVVREFLTRNPAWR
KAVFISPYNSQNAVASKILGLPTQTVDSSQGSEYDYVIFTQTTETAHSCN
VNRFNVAITRAKVGILCIMSDRDLYDKLQFTSLEIP
3D structure
PDB8gwe A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors.
ChainE
Resolution2.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E H33 H39 H33 H39
BS02 ZN E C8 C26 C8 C26
BS03 ZN E C55 C72 H75 C55 C72 H75
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:8gwe, PDBe:8gwe, PDBj:8gwe
PDBsum8gwe
PubMed36335936
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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