Structure of PDB 8gae Chain E

Receptor sequence
>8gaeE (length=459) Species: 9606 (Homo sapiens) [Search protein sequence]
GALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPSNAIYYGNRSLAY
LRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYETV
VKVKPHDKDAKMKYQECNKIVKQKAFERAIAGDEHKRSVVDSLDIESMTI
EDEYSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSK
LSTLVETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDF
VDRGSFSVEVILTLFGFKLLYPDHFHLLRGNAETDNMNQIYGFEGEVKAK
YTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERN
RQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDY
IIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQ
FHQFTAVPH
3D structure
PDB8gae Hsp90 provides a platform for kinase dephosphorylation by PP5.
ChainE
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN E D242 H244 D271 Y451 D220 H222 D249 Y429
BS02 MN E D271 N303 H352 H427 D249 N281 H330 H405
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008289 lipid binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0017018 myosin phosphatase activity
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0046872 metal ion binding
GO:0048156 tau protein binding
GO:0051879 Hsp90 protein binding
Biological Process
GO:0000165 MAPK cascade
GO:0000278 mitotic cell cycle
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006351 DNA-templated transcription
GO:0006470 protein dephosphorylation
GO:0010288 response to lead ion
GO:0035970 peptidyl-threonine dephosphorylation
GO:0043123 positive regulation of canonical NF-kappaB signal transduction
GO:0043278 response to morphine
GO:0070262 peptidyl-serine dephosphorylation
GO:1904550 response to arachidonate
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0032991 protein-containing complex
GO:0043231 intracellular membrane-bounded organelle
GO:0101031 protein folding chaperone complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8gae, PDBe:8gae, PDBj:8gae
PDBsum8gae
PubMed37069154
UniProtP53041|PPP5_HUMAN Serine/threonine-protein phosphatase 5 (Gene Name=PPP5C)

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