Structure of PDB 8g9v Chain E

Receptor sequence

>8g9vE (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]

GNIILEILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGR
QTTYEFAKRKSRLVLWDINKHGVEETAAECRKLGVTAHAYVVDCSNREEI
YRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFW
ITKALLPSMMKRNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLT
SELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSLIDGI
LTNKKMIFVPSYINIFLRLQKFLPERASAILNRMQNIQFEAVV

3D structure

PDB

8g9v Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13.

Chain

Resolution

2.645 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.-
1.1.1.105: all-trans-retinol dehydrogenase (NAD(+)).
1.1.1.62: 17beta-estradiol 17-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	E	G43 H46 G47 I48 D67 I68 D93 C94 N120 A121 G122 V170 S172 Y185 K189 P218 F220 V221 T223 F225	G43 H46 G47 I48 D67 I68 D93 C94 N120 A121 G122 V170 S172 Y185 K189 P218 F220 V221 T223 F225
BS02	YYC	E	S172 V173 C174 I179 Y185 V219 F220 F225 W234 F266	S172 V173 C174 I179 Y185 V219 F220 F225 W234 F266

External links

PDB	RCSB:8g9v, PDBe:8g9v, PDBj:8g9v
PDBsum	8g9v
PubMed	37620305
UniProt	Q7Z5P4\|DHB13_HUMAN 17-beta-hydroxysteroid dehydrogenase 13 (Gene Name=HSD17B13)

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