Structure of PDB 8foi Chain E

Receptor sequence
>8foiE (length=333) Species: 10090 (Mus musculus) [Search protein sequence]
PSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNM
DYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSF
VHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
SYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSY
PRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGI
TTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYI
FFGDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN
3D structure
PDB8foi Cryo-EM structures reveal native GABA A receptor assemblies and pharmacology.
ChainE
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y4B E A300 Y304 A295 Y299
BS02 ABU E Y157 T202 Y205 Y152 T197 Y200
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0004890 GABA-A receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8foi, PDBe:8foi, PDBj:8foi
PDBsum8foi
PubMed37730991
UniProtP63137|GBRB2_MOUSE Gamma-aminobutyric acid receptor subunit beta-2 (Gene Name=Gabrb2)

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