Structure of PDB 8fk4 Chain E

Receptor sequence
>8fk4E (length=829) Species: 1309 (Streptococcus mutans) [Search protein sequence]
YKKYNQVYDRSAQSFEHVDHYLTAESWYRPKYILKDGKTWTQSTEKDFRP
LLMTWWPSQETQRQYVNYMNAQLGINKTYDDTSNQLQLNIAAATIQAKIE
AKITTLKNTDWLRQTISAFVKTQSAWNSDSEKPFDDHLQNGAVLYDNEGK
LTPYANSNYRILNRTPTNQTGKKDPRYTADNTIGGYEFLLANDVDNSNPV
VQAEQLNWLHFLMNFGNIYANDPDANFDSIRVDAVDNVDADLLQIAGDYL
KAAKGIHKNDKAANDHLSILEAWSDNDTPYLHDDGDNMINMDNKLRLSLL
FSLAKPLNQRSGMNPLITNSLVNRTDDNAETAAVPSYSFIRAHDSEVQDL
IRDIIKAEINPNVVGYSFTMEEIKKAFEIYNKDLLATEKKYTHYNTALSY
ALLLTNKSSVPRVYYGDMFTDDGQYMAHKTINYEAIETLLKARIKYVSGG
QAMRNQQVGNSEIITSVRYGKGALKATDTGDRTTRTSGVAVIEGNNPSLR
LKASDRVVVNMGAAHKNQAYRPLLLTTDNGIKAYHSDQEAAGLVRYTNDR
GELIFTAADIKGYANPQVSGYLGVWVPVGAAADQDVRVAASTAPSTDGKS
VHQNAALDSRVMFEGFSNFQAFATKKEEYTNVVIAKNVDKFAEWGVTDFE
MAPQYVSSTDGSFLDSVIQNGYAFTDRYDLGISKPNKYGTADDLVKAIKA
LHSKGIKVMADWVPDQMYAFPEKEVVTATRVDKFGKPVEGSQIKSVLYVA
DSKSSGKDQQAKYGGAFLEELQAKYPELFARKQISTGVPMDPSVKIKQWS
AKYFNGTNILGRGAGYVLKDQATNTYFNI
3D structure
PDB8fk4 The catalytic domains of Streptococcus mutans glucosyltransferases: a structural analysis
ChainE
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.5: dextransucrase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC E N511 R514 N293 R296
BS02 GLC E Y404 W491 Y186 W273
BS03 AC1 E D451 E489 W491 H561 D562 D883 Y890 Q934 D233 E271 W273 H343 D344 D665 Y672 Q716
BS04 CA E E405 D411 N455 D933 E187 D193 N237 D715
Gene Ontology
Molecular Function
GO:0046527 glucosyltransferase activity
Biological Process
GO:0009250 glucan biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8fk4, PDBe:8fk4, PDBj:8fk4
PDBsum8fk4
PubMed37158310
UniProtP08987|GTFB_STRMU Glucosyltransferase-I (Gene Name=gtfB)

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