Structure of PDB 8fe7 Chain E

Receptor sequence
>8fe7E (length=705) Species: 9606 (Homo sapiens) [Search protein sequence]
SCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVL
QQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRA
IQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAH
CLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRK
AIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTS
HLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCN
GKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGA
LFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVI
DFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKALNMPVIPMNTIAE
AVIEMINRGQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQ
YGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEP
NIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGM
DVLWAGTPMVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLG
TDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPD
HMIKP
3D structure
PDB8fe7 Crystal structure of human O-GlcNAc transferase (OGT) in complex with an exosite-binding peptide (SMG9) and UDP-GlcNAc
ChainE
Resolution2.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.255: protein O-GlcNAc transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E K714 I777 I780 N781 G783 S823 G826 L827 K403 I453 I456 N457 G459 S499 G502 L503
BS02 UD1 E H498 P559 T560 P656 Q839 K842 L866 V895 A896 K898 H901 H920 T921 T922 D925 H187 P248 T249 P345 Q515 K518 L542 V571 A572 K574 H577 H596 T597 T598 D601
External links
PDB RCSB:8fe7, PDBe:8fe7, PDBj:8fe7
PDBsum8fe7
PubMed37653170
UniProtO15294|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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