Structure of PDB 8ek8 Chain E

Receptor sequence
>8ek8E (length=90) Species: 9606 (Homo sapiens) [Search protein sequence]
KIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKG
NRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGEVLG
3D structure
PDB8ek8 DNA selection by the master transcription factor PU.1.
ChainE
Resolution2.63 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E S203 K206 Q226 R230 R233 K243 L248 S35 K38 Q58 R62 R65 K75 L80
BS02 dna E R171 L172 W213 K217 N219 K221 M223 K227 Y235 K247 R3 L4 W45 K49 N51 K53 M55 K59 Y67 K79
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:8ek8, PDBe:8ek8, PDBj:8ek8
PDBsum8ek8
PubMed37352101
UniProtP17947|SPI1_HUMAN Transcription factor PU.1 (Gene Name=SPI1)

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