Structure of PDB 8eik Chain E

Receptor sequence
>8eikE (length=378) Species: 9606 (Homo sapiens) [Search protein sequence]
EDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTVC
CEGRELLLCSNTSCCRCFCVECLEVLVGQRCHGVLRRRKDWNVRLQAFFT
SDYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASE
VCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCGLYE
GTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLEC
NPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIA
KLKKVQTITTKSLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGA
RQKLLGRSWSVPVIRHLFAPLKDYFACE
3D structure
PDB8eik Cryo-EM structure of human DNMT3B homo-hexamer
ChainE
Resolution3.19 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E H677 F713 H211 F247
BS02 ZN E L454 C455 C458 L23 C24 C27
BS03 ZN E C478 V480 C481 C47 V49 C50
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0009008 DNA-methyltransferase activity
Biological Process
GO:0010468 regulation of gene expression

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8eik, PDBe:8eik, PDBj:8eik
PDBsum8eik
PubMed37941146
UniProtQ9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

[Back to BioLiP]