Structure of PDB 8e14 Chain E

Receptor sequence
>8e14E (length=269) Species: 11888 (Rous sarcoma virus - Prague C) [Search protein sequence]
PLREAKDLHTALHIGPRALSKACNISMQQAREVVQTCPHCNSAPALEAGV
NPRGLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTSVA
VQHHWATAIAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTGIPGNS
QGQAMVERANRLLKDKIRVLAEGDGFMKRIPTSKQGELLAKAMYALNHFE
RGENTKTPIQKHWRPTVLTEGPPVKIRIETGEWEKGWNVLVWGRGYAAVK
NRDTDKVIWVPSRKVKPDI
3D structure
PDB8e14 Molecular determinants for Rous sarcoma virus intasome assemblies involved in retroviral integration.
ChainE
Resolution3.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E S150 E157 R161 K164 S150 E157 R161 K164
BS02 dna E G49 V50 N51 P52 G145 I146 Q151 R158 R244 G49 V50 N51 P52 G145 I146 Q151 R158 R244
BS03 dna E R95 V96 T97 S98 S128 K129 R95 V96 T97 S98 S128 K129
BS04 dna E D121 N122 D121 N122
BS05 ZN E H9 H13 C40 H9 H13 C40
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:8e14, PDBe:8e14, PDBj:8e14
PDBsum8e14
PubMed37084813
UniProtP03354|POL_RSVP Gag-Pol polyprotein (Gene Name=gag-pol)

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