Structure of PDB 8dus Chain E

Receptor sequence
>8dusE (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
SLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMI
NWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNL
LLDRNQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGV
YTTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMKVPSYDLLLEMLDAHR
3D structure
PDB8dus Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells.
ChainE
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TWF E L346 A350 D351 E353 W383 F404 M421 I424 H524 L525 L38 A42 D43 E45 W75 F96 M113 I116 H212 L213
External links
PDB RCSB:8dus, PDBe:8dus, PDBj:8dus
PDBsum8dus
PubMed36517522
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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