Structure of PDB 8dgs Chain E

Receptor sequence
>8dgsE (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKHK
3D structure
PDB8dgs Cryo-EM structure of a RAS/RAF recruitment complex.
ChainE
Resolution4.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG E S17 T35 S17 T35
BS02 GNP E G13 G15 K16 S17 A18 F28 V29 D30 E31 Y32 P34 T35 G60 N116 K117 D119 S145 A146 G13 G15 K16 S17 A18 F28 V29 D30 E31 Y32 P34 T35 G60 N116 K117 D119 S145 A146
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:8dgs, PDBe:8dgs, PDBj:8dgs
PDBsum8dgs
PubMed37516774
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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