Structure of PDB 8d1k Chain E

Receptor sequence
>8d1kE (length=376) Species: 9606 (Homo sapiens) [Search protein sequence]
TITYTSQVANARLGSFSRLLLCWRGSIYKLLYGEFLIFLLCYYIIRFIYR
LALTEEQQLMFEKLTLYCDSYIQLIPISFVLGFYVTLVVTRWWNQYENLP
WPDRLMSLVSGFVEGKDEQGRLLRRTLIRYANLGNVLILRSVSTAVYKRF
PSAQHLVQAGFMTPAEHKQLEKLSLPHNMFWVPWVWFANLSMKAWLGGRI
RDPILLQSLLNEMNTLRTQCGHLYAYDWISIPLVYTQVVTVAVYSFFLTC
LVGRQFLNPAKAYPGHELDLVVPVFTFLQFFFYVGWLKVAEQLINPFGED
DDDFETNWIVDRNLQVSLLAVDEMHQDLPRMEPDMYWNKPEPQPPYTAAS
AQFRRASFMGSTFNISLNKEEMEFQP
3D structure
PDB8d1k Structures and gating mechanisms of human bestrophin anion channels.
ChainE
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA E Q293 N296 D301 D304 Q292 N295 D300 D303
Gene Ontology
Molecular Function
GO:0005229 intracellularly calcium-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0022834 ligand-gated channel activity
GO:0022857 transmembrane transporter activity
GO:0042802 identical protein binding
GO:0160133 bicarbonate channel activity
Biological Process
GO:0006821 chloride transport
GO:0007601 visual perception
GO:0014047 glutamate secretion
GO:0015701 bicarbonate transport
GO:0030321 transepithelial chloride transport
GO:0034220 monoatomic ion transmembrane transport
GO:0048167 regulation of synaptic plasticity
GO:0050908 detection of light stimulus involved in visual perception
GO:0051259 protein complex oligomerization
GO:0051924 regulation of calcium ion transport
GO:0061534 gamma-aminobutyric acid secretion, neurotransmission
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0034707 chloride channel complex
GO:0098793 presynapse
GO:0098857 membrane microdomain

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Biological Process
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Cellular Component
External links
PDB RCSB:8d1k, PDBe:8d1k, PDBj:8d1k
PDBsum8d1k
PubMed35789156
UniProtO76090|BEST1_HUMAN Bestrophin-1 (Gene Name=BEST1)

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