Structure of PDB 8d0k Chain E

Receptor sequence
>8d0kE (length=431) Species: 9606 (Homo sapiens) [Search protein sequence]
DQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVK
GTEQYQSKLESELRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEE
LRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQE
IVASSPSLSGLKLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIV
AIILNEFRAKLSKALALTARSLPAVQSDERLQPLLNHLSHSGNVGKISLD
QIDLLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLTLEQAL
QFWKQEFIKGKMDPDKFDKGYSYNIRHSFGKEGKRTDYTPFSCLKIILSN
PPSQGDYHGCPFRHSDPELLKQKLQSYKISPGGISQILDLVKGTHYQVAC
QKYFEMIHNVDDCGFSLNHPNQFFCESQRIL
3D structure
PDB8d0k Structures of the human CST-Pol alpha-primase complex bound to telomere templates.
ChainE
Resolution4.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E Y347 H351 E356 G357 K358 Y323 H327 E332 G333 K334
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0071667 DNA/RNA hybrid binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006269 DNA replication, synthesis of primer
GO:0006270 DNA replication initiation
GO:1903934 positive regulation of DNA primase activity
Cellular Component
GO:0005654 nucleoplasm
GO:0005658 alpha DNA polymerase:primase complex
GO:1990077 primosome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8d0k, PDBe:8d0k, PDBj:8d0k
PDBsum8d0k
PubMed35830881
UniProtP49643|PRI2_HUMAN DNA primase large subunit (Gene Name=PRIM2)

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