Structure of PDB 8c9h Chain E

Receptor sequence
>8c9hE (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
QEILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVLNKKYGSYLGVNLGFG
FGVTMGVHVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQFLGSFL
AAATIYSLFYTAILHFSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNE
AWLTGMLQLCLFAITDQENNPALPGTEALVIGILVVIIGVSLGMNTGYAI
NPSRDLPPRIFTFIAGWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVF
IGS
3D structure
PDB8c9h AQP7_inhibitor
ChainE
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T60 E F74 A91 H92 Q183 F187 I206 F49 A66 H67 Q158 F162 I181
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015204 urea transmembrane transporter activity
GO:0015250 water channel activity
GO:0015254 glycerol channel activity
GO:0015267 channel activity
Biological Process
GO:0006833 water transport
GO:0015791 polyol transmembrane transport
GO:0015793 glycerol transmembrane transport
GO:0055085 transmembrane transport
GO:0071918 urea transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005811 lipid droplet
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005938 cell cortex
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c9h, PDBe:8c9h, PDBj:8c9h
PDBsum8c9h
PubMed38319972
UniProtO14520|AQP7_HUMAN Aquaporin-7 (Gene Name=AQP7)

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